I suppose it's hard to pin MisterWives down to an exact genre. I would say they're a mix between modern pop and folk, something very similar to Of Monsters and Men. Now, about those vocals... WOW. Mandy Lee has the most endearing and sincere vocals that have ever graced my ears. She manages to melt my heart and pull on every single one of my heartstrings all in the space of three minutes.
The song speaks to me in so many ways and I absolutely love the entire arrangement, especially those subtle but haunting strings in the background. If this doesn't put MisterWives on the map, I honestly don't know what will.